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Ann N Y Acad Sci. 2006 Oct;1082:52-5.

Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice.

Author information

1
SomaGenics, Inc., Santa Cruz, CA 95060, USA.

Abstract

The ability of small hairpin RNAs (shRNAs) to inhibit hepatitis C virus internal ribosome entry site (HCV IRES)-dependent gene expression was investigated in cultured cells and a mouse model. The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses.

PMID:
17145925
DOI:
10.1196/annals.1348.060
[Indexed for MEDLINE]

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