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Cancer Res. 2006 Dec 1;66(23):11085-8.

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

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1
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892-4340, USA.

Abstract

Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E(2), the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein-dependent signaling pathway coupling the prostaglandin EP2 receptor to beta-catenin control. These findings provide new insights into the molecular framework needed to evaluate chemopreventive strategies for colorectal cancer.

PMID:
17145847
DOI:
10.1158/0008-5472.CAN-06-2233
[Indexed for MEDLINE]
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