Expression of semaphorin 6D in gastric carcinoma and its significance

World J Gastroenterol. 2006 Dec 7;12(45):7388-90. doi: 10.3748/wjg.v12.i45.7388.

Abstract

Aim: To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.

Methods: The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative reverse transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.

Results: The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 +/- 0.06 vs 0.19 +/- 0.07, 0.26 +/- 0.09 vs 0.20 +/- 0.10, P < 0.05).

Conclusion: Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis.

MeSH terms

  • Adult
  • Aged
  • Cell Differentiation
  • Female
  • Gastric Mucosa / pathology*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Male
  • Middle Aged
  • Neovascularization, Pathologic / genetics
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • Semaphorins / genetics*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery

Substances

  • RNA, Messenger
  • RNA, Neoplasm
  • Semaphorins