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Comp Biochem Physiol B. 1991;98(4):549-53.

The role of alpha 2-macroglobulin in furunculosis: a comparison of rainbow trout and brook trout.

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1
Department of Fisheries and Wildlife, Utah State University, Logan 84322.

Abstract

1. The molecular basis for the high survival rate of rainbow trout, Oncorhynchus mykiss, infected with furunculosis was investigated. 2. Alpha 2-macroglobulin (alpha 2M), a major serum protease inhibitor, was partially purified from rainbow trout and brook trout, Salvelinus fontinalis, sera; the latter species shows marked disease susceptibility. 3. It is shown that a 10-fold species-based difference in alpha 2M inhibitory activity exists against a furunculosis associated bacterial protease. 4. A possible basis for the observed disparity is discussed. 5. Results suggest that the high mol. wt form of teleost (trout) albumin is a dimer composed of two 85,000 subunits.

PMID:
1714367
[Indexed for MEDLINE]
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