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Intensive Care Med. 2007 Feb;33(2):255-60. Epub 2006 Dec 2.

Serum S-100B protein monitoring in patients with severe traumatic brain injury.

Author information

1
Department of Neurosurgery, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK. Stefanos.Korfias@NUTH.NHS.UK

Abstract

OBJECTIVE:

S-100B protein is a promising marker of injury severity and outcome after head injury. We examined the relationship between serum S-100B concentrations and injury severity, clinical course, survival, and treatment efficacy after severe traumatic brain injury (TBI).

DESIGN AND SETTING:

Prospective observational study in a neurosurgical intensive care unit.

PATIENTS AND PARTICIPANTS:

102 adult patients with severe TBI, admitted between June 2001 and November 2003 (30 months).

INTERVENTIONS:

Serum S-100B levels were measured by immunoluminometric technique on admission and every 24 h thereafter for a maximum of 7 days.

MEASUREMENTS AND RESULTS:

Initial S-100B levels were significantly related to pupillary status, computed tomography severity 1, and 1-month survival. Cox's proportional hazard regression analysis showed that initial S-100B was an independent predictor of 1-month survival, in the presence of dilated pupils, and with increased age. Subjects with initial levels above 1 microg/l had a nearly threefold increased probability of death within 1 month. Serum S-100B alteration indicated neurological improvement or deterioration. Finally, surgical treatment reduced S-100B levels.

CONCLUSIONS:

Serum S-100B protein reflects injury severity and improves prediction of outcome after severe TBI. S-100B may also have a role in assessing the efficacy of treatment after severe TBI.

PMID:
17143637
DOI:
10.1007/s00134-006-0463-4
[Indexed for MEDLINE]

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