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Cancer Immunol Immunother. 2007 May;56(5):731-7. Epub 2006 Dec 2.

Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy.

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Tumorgenetik, Klinik I für Innere Medizin, and Zentrum für Molekulare Medizin Köln, Klinikum der Universität zu Köln, Köln, Germany.


Redirecting T cell effector functions towards pre-defined target cells represents an attractive concept in the adoptive immunotherapy of malignant diseases. Our understanding of the mechanisms of T cell activation and costimulation as well as the design of recombinant T cell receptors have made major progress in the last years. Translating recent concepts of T cell stimulation into recombinant protein design provides the basis to engineer T cells with both pre-defined specificity and costimulatory capacity in order to enhance anti-tumor immunity and to break tolerance. Dual signaling immunoreceptors providing the CD3zeta signal simultaneously with an appropriate costimulatory signal moreover allows to modulate the quality of the anti-tumor T cell response in a predicted fashion.

[Indexed for MEDLINE]

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