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J Clin Invest. 2006 Dec;116(12):3090-100.

Molecular regulation of HDL metabolism and function: implications for novel therapies.

Author information

1
Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA. rader@mail.med.upenn.edu

Abstract

HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.

PMID:
17143322
PMCID:
PMC1679714
DOI:
10.1172/JCI30163
[Indexed for MEDLINE]
Free PMC Article
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