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Nat Methods. 2007 Jan;4(1):31-3. Epub 2006 Dec 3.

Tomographic molecular imaging and 3D quantification within adult mouse organs.

Author information

1
Umeå Center for Molecular Medicine, Umeå University, S-901 87, Umeå, Sweden.

Abstract

A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined improvements in sample preparation, tomographic imaging and computational processing, we present a procedure for high-resolution 3D quantification of structures within intact adult mouse organs. Using the nonobese diabetic (NOD) mouse model, we demonstrate a correlation between total islet beta-cell volume and the onset of type-1 diabetes.

PMID:
17143281
DOI:
10.1038/nmeth985
[Indexed for MEDLINE]

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