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J Antimicrob Chemother. 2007 Feb;59(2):301-4. Epub 2006 Dec 1.

Differences in biofilm development and antibiotic susceptibility among Streptococcus pneumoniae isolates from cystic fibrosis samples and blood cultures.

Author information

1
Servicio de Microbiología, Hospital Universitario Ramón y Cajal Ctra. Colmenar Km 9.1, Madrid 28034, Spain.

Abstract

OBJECTIVES:

To compare the capability of biofilm development between Streptococcus pneumoniae isolates from cystic fibrosis (CF) respiratory samples and those from non-CF blood cultures. Antibiotic susceptibility of biofilm-forming isolates, as well as differences between antibiotic susceptibility of sessile cells [minimum biofilm inhibitory concentration (MBIC)] and their planktonic counterparts (conventional MIC), were also assessed.

METHODS:

Biofilm formation was performed using a microtitre method in 20 CF and 22 non-CF blood culture S. pneumoniae isolates.

RESULTS AND CONCLUSIONS:

Biofilm formation occurs more frequently among S. pneumoniae isolates from CF (80%) than among non-CF blood culture isolates (50%) (P = 0.04). Moreover MBICs were significantly higher than conventional planktonic MICs among CF but not among non-CF blood isolates, suggesting a high adaptability of CF strains to form biofilms in adverse conditions.

PMID:
17142818
DOI:
10.1093/jac/dkl482
[Indexed for MEDLINE]

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