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Biochim Biophys Acta. 2007 Apr;1768(4):756-71. Epub 2006 Oct 4.

The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

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1
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. birnbau1@niehs.nih.gov

Abstract

The realization that there existed a G-protein coupled signal transduction mechanism developed gradually and was initially the result of an ill fated quest for uncovering the mechanism of action of insulin, followed by a refocused research in many laboratories, including mine, on how GTP acted to increase hormonal stimulation of adenylyl cyclase. Independent research into how light-activated rhodopsin triggers a response in photoreceptor cells of the retina and the attendant biochemical studies joined midway and, without the left hand knowing well what the right hand was doing, preceded classical G protein research in identifying the molecular players responsible for signal transduction by G proteins.

PMID:
17141178
PMCID:
PMC1894990
DOI:
10.1016/j.bbamem.2006.09.027
[Indexed for MEDLINE]
Free PMC Article
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