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Expert Rev Mol Diagn. 2006 Nov;6(6):857-64.

Diagnosis of pertussis: a historical review and recent developments.

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AMW, 1190 St. Francis Dr., Suite N1320, Santa Fe, NM 87505, USA.


The accurate and timely diagnosis of pertussis continues to be challenging. The widespread use of pertussis vaccines has dramatically altered the epidemiology and clinical presentation of pertussis disease, such that many cases do not present with the hallmark symptoms, such as inspiratory whoop, post-tussive vomiting and paroxysmal cough. A variety of laboratory tools are available to aid in the diagnosis of pertussis, including culture, direct fluorescent antibody testing, PCR, and paired and single serology techniques. This article reviews the strengths and limitations, including the sensitivity and specificity, of each of these diagnostic tools.

[Indexed for MEDLINE]

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