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Nat Rev Mol Cell Biol. 2006 Dec;7(12):909-18.

Membrane-protein topology.

Author information

1
Center for Biomembrane Research and Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm. gunnar@dbb.su.se

Abstract

In the world of membrane proteins, topology defines an important halfway house between the amino-acid sequence and the fully folded three-dimensional structure. Although the concept of membrane-protein topology dates back at least 30 years, recent advances in the field of translocon-mediated membrane-protein assembly, proteome-wide studies of membrane-protein topology and an exponentially growing number of high-resolution membrane-protein structures have given us a deeper understanding of how topology is determined and of how it evolves.

PMID:
17139331
DOI:
10.1038/nrm2063
[Indexed for MEDLINE]

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