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Nat Rev Mol Cell Biol. 2006 Dec;7(12):897-908. Epub 2006 Nov 8.

Powering membrane traffic in endocytosis and recycling.

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Départment de Biochimie, Faculté des Sciences, Université de Genève, 30 quai Ernest Ansermet, Sciences II, CH-1211-Genève-4, Switzerland.


Early in evolution, the diversification of membrane-bound compartments that characterize eukaryotic cells was accompanied by the elaboration of molecular machineries that mediate intercompartmental communication and deliver materials to specific destinations. Molecular motors that move on tracks of actin filaments or microtubules mediate the movement of organelles and transport between compartments. The subjects of this review are the motors that power the transport steps along the endocytic and recycling pathways, their modes of attachment to cargo and their regulation.

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