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Br J Sports Med. 2007 Mar;41(3):134-9. Epub 2006 Nov 30.

Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries.

Author information

1
Centro Médico Juan XXIII, Murcia, Spain. fesparza@pdi.ucam.edu

Abstract

OBJECTIVE:

To compare the ketoprofen TDS patch with diclofenac gel in the treatment of traumatic acute pain in benign sport-related soft-tissue injuries.

DESIGN:

7-14 treatment days, prospective, randomised, open study.

PATIENTS:

Outpatients aged 18-70 years diagnosed for painful benign sport-related soft-tissue injury (sprains, strains and contusions within the prior 48 h), randomised to either ketoprofen patch 100 mg once daily (n = 114) or diclofenac gel 2-4 g three times daily (n = 109).

INTERVENTION:

7-14 days of topical non-steroidal anti-inflammatory drugs treatment to assess the pain intensity changes (daily activities and spontaneous at rest) in a daily diary (100-mm Visual Analogue Scale (VAS)).

MAIN OUTCOME MEASUREMENT:

Pain intensity (VAS).

RESULTS:

The ketoprofen patch was not inferior to diclofenac gel in reducing the baseline pain during daily activities (difference of -1.17 mm in favour of ketoprofen patch, 95% CI (-5.86 to 3.52), reducing to the baseline VAS 79%. Ketoprofen patch presented also a higher cure rate (64%) than diclofenac gel (46%) at day 7 (p = 0.004). Patient opinions about the treatment comfort (pharmaceutical shape, application and dosage) were also statistically higher for the ketoprofen patch (>80% of the patients rated as good or excellent the patch removal and skin adherence).

CONCLUSION:

Ketoprofen patches are effective and safe pain relievers for the treatment of sports injury pain with advantages compared with diclofenac gel.

PMID:
17138642
PMCID:
PMC2465231
DOI:
10.1136/bjsm.2006.030239
[Indexed for MEDLINE]
Free PMC Article

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