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FEBS Lett. 1991 Jul 29;286(1-2):9-12.

Keratinization is associated with the expression of a new protein related to the desmosomal cadherins DGII/III.

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Dermatology Research Group, Clinical Research Centre, Harrow, Middlesex, UK.


Amino acid sequencing of a 48/46 kDa glycoprotein from human plantar callus, recognised by antisera raised against the desmosomal cadherins DGII/III, has revealed N-terminal homology to the DNA-derived sequence of human and bovine DGII/III. However, a tryptic fragment has homology only with a bovine clone. We propose that there are two classes of DGII/III-like molecule, that represented by the bovine cDNA clone and the 48/46 kDa protein, a monoclonal antibody against which stains mainly the suprabasal layers of human epidermis, and that represented by the human cDNA clone, identified by a monoclonal antibody which stains uniformly the living layers of the epidermis.

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