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Amino Acids. 2007;32(4):523-6. Epub 2006 Nov 30.

Regulation of apoptosis by protein S-nitrosylation.

Author information

1
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A. joan.mannick@umassmed.edu

Abstract

S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.

PMID:
17136512
DOI:
10.1007/s00726-006-0427-6
[Indexed for MEDLINE]

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