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Pharmacol Rev. 2006 Dec;58(4):742-59.

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor.

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  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. moore@bcm.tmc.edu

Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

PMID:
17132852
DOI:
10.1124/pr.58.4.6
[PubMed - indexed for MEDLINE]
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