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Methods Enzymol. 2006;417:293-339.

Helicobacter pylori adhesion to carbohydrates.

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1
Department of Molecular Biosciences, University of Oslo, Oslo, Norway.

Abstract

Adherence of bacterial pathogens to host tissues contributes to colonization and virulence and typically involves specific interactions between bacterial proteins called adhesins and cognate oligosaccharide (glycan) or protein motifs in the host that are used as receptors. A given pathogen may have multiple adhesins, each specific for a different set of receptors and, potentially, with different roles in infection and disease. This chapter provides strategies for identifying and analyzing host glycan receptors and the bacterial adhesins that exploit them as receptors, with particular reference to adherence of the gastric pathogen Helicobacter pylori.

PMID:
17132512
PMCID:
PMC2576508
DOI:
10.1016/S0076-6879(06)17020-2
[Indexed for MEDLINE]
Free PMC Article
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