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Mol Syst Biol. 2006;2:64. Epub 2006 Nov 28.

Dynamics of single-cell gene expression.

Author information

1
Department of Bioengineering, University of California at San Diego, La Jolla, CA 92093-0412, USA. hasty@ucsd.edu

Abstract

Cellular behavior has traditionally been investigated by utilizing bulk-scale methods that measure average values for a population of cells. Such population-wide studies mask the behavior of individual cells and are often insufficient for characterizing biological processes in which cellular heterogeneity plays a key role. A unifying theme of many recent studies has been a focus on the development and utilization of single-cell experimental techniques that are capable of probing key biological phenomena in individual living cells. Recently, novel information about gene expression dynamics has been obtained from single-cell experiments that draw upon the unique capabilities of fluorescent reporter proteins.

PMID:
17130866
PMCID:
PMC1682029
DOI:
10.1038/msb4100110
[Indexed for MEDLINE]
Free PMC Article
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