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Kidney Int. 2006 Dec;70(11):1891-3.

4-Hydroxyproline metabolism and glyoxylate production: A target for substrate depletion in primary hyperoxaluria?

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1
Department of Pediatrics, University of British Columbia, Vancouver, Canada. marioncm@interchange.ubc.ca

Abstract

The primary hyperoxalurias are diseases of overproduction of oxalate. The immediate precursor of oxalate is glyoxylate. Metabolism of hydroxyproline, derived from collagen turnover or the diet, appears to be a major source of glyoxylate, and a potential target for a therapeutic strategy of substrate depletion.

PMID:
17130820
DOI:
10.1038/sj.ki.5001987
[Indexed for MEDLINE]
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