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Neurology. 2006 Nov 28;67(10):1852-4.

Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging.

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Department of Ophthalmology, University of Auckland, Auckland. New Zealand.


In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.

[Indexed for MEDLINE]

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