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Acta Paediatr. 2006 Dec;95(12):1665-7.

Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations.

Author information

1
Bonkolab 5704, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. ninatoft@yahoo.com

Abstract

AIM:

To determine the frequency of thiopurine methyltransferase (TPMT) low-activity alleles in the Greenlandic and Danish populations.

METHODS:

142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low-activity alleles.

RESULTS:

Thiopurine methyltransferase low-activity alleles were significantly higher in the Greenlandic compared to the Danish population, being 8.1% (95% CI 4.9-11.3) and 3.5% (95% CI 1.7-5.3) (p<0.01), respectively. Except for one Danish patient with an A719G allele (TPMT*3C), all the aberrant alleles were compound G460A and A719G alleles (TPMT*3A).

CONCLUSION:

In the Danish population, the incidence of thiopurine methyltransferase low-activity alleles was found to be similar to other Caucasian populations previously described. In contrast, the Greenlandic population showed a significantly higher frequency of thiopurine methyltransferase low-activity alleles.

PMID:
17129980
DOI:
10.1080/08035250600743788
[Indexed for MEDLINE]
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