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Bioorg Med Chem Lett. 2007 Feb 15;17(4):1052-5. Epub 2006 Nov 15.

Design and synthesis of a novel class of dual PPARgamma/delta agonists.

Author information

1
Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate center, Indianapolis, IN 46285, USA. gonzalez_isabel_c@lilly.com

Abstract

The design and synthesis of dual PPAR gamma/delta agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.

PMID:
17129725
DOI:
10.1016/j.bmcl.2006.11.029
[Indexed for MEDLINE]

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