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Biochem Biophys Res Commun. 2007 Jan 12;352(2):543-8. Epub 2006 Nov 20.

High molecular weight adiponectin reduces apolipoprotein B and E release in human hepatocytes.

Author information

1
Department of Internal Medicine I, Regensburg University Medical Center, D-93042 Regensburg, Germany.

Abstract

Low circulating levels of high molecular weight adiponectin (HMW-Apm) have been linked to dyslipidaemia and systemic HMW-Apm negatively correlates with very low density lipoprotein (VLDL), apolipoprotein B (ApoB), and ApoE and is positively associated with ApoA-I. Therefore, it was investigated whether HMW-Apm alters the hepatic synthesis of ApoB, ApoE, and ApoA-I or the activity of the hepatic ATP-binding cassette transporter A1 (ABCA1), as the main determinant of plasma HDL. HMW-Apm reduces hepatic ApoB and ApoE release whereas ABCA1 protein, activity and ApoA-I were not altered. Global gene expression analysis revealed that hepatic nuclear factor 4-alpha (HNF4-alpha) and HNF4-alpha regulated genes like ApoB are downregulated by HMW-Apm and this was confirmed at the mRNA and protein level. Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced.

PMID:
17129575
DOI:
10.1016/j.bbrc.2006.11.058
[Indexed for MEDLINE]

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