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Bioorg Med Chem Lett. 2007 Feb 15;17(4):1047-51. Epub 2006 Nov 16.

Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.

Author information

1
Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. mletavic@prdus.jnj.com

Abstract

A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H(3) ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.

PMID:
17127059
DOI:
10.1016/j.bmcl.2006.11.036
[Indexed for MEDLINE]

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