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Exp Gerontol. 2006 Dec;41(12):1213-6. Epub 2006 Nov 28.

Drosophila aging 2005/06.

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  • 1Centre for Neuroscience and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.


Drosophila continues to be a model system of choice to study the genetics of aging. It has a short lifespan and small genome size, but nevertheless contains a complex organ and endocrine system that allows studying the role of conserved signal transduction pathways with sophisticated genetic tools. Oxidative stress and metabolic changes along with intersecting signaling systems Insulin Receptor (InR), Target of Rapamycin (TOR) and Jun N-terminal Kinase (JNK) have emerged as some of the major players in aging. Sleep and organ-specific aging has also been the subject of recent progress in understanding aging.

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