Format

Send to

Choose Destination
J Cell Mol Med. 2006 Oct-Dec;10(4):857-65.

Tumor stroma fosters neovascularization by recruitment of progenitor cells into the tumor bed.

Author information

1
Laboratory for Cancer Medicine, Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Perth WA 6000, Australia. ganss@waimr.uwa.edu.au

Abstract

The tumor stroma is an active player during carcinogenesis and contains a variety of cell types such as vascular cells, fibroblasts and inflammatory cells which directly or indirectly foster neovascularization. During tumor progression stromal cells, in particular the neovasculature, acquire new characteristics distinct from their normal counterparts and display a high degree of plasticity to meet the tumor's demands. The local environment may, to some extent, shape pre-existing, tumor-resident stromal cells. However, there is accumulating evidence that new endothelial and other stromal cells are actively recruited into tumors, and that this recruitment is essential for a unique and tumor-specific proangiogenic environment.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center