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Nat Rev Immunol. 2006 Dec;6(12):930-9.

Progress and obstacles in the development of an AIDS vaccine.

Author information

1
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. nletvin@bidmc.harvard.edu

Abstract

Recent experimental observations suggest approaches to immunization that might finally result in at least a partially effective vaccine against infection with HIV-1. In particular, advances in our understanding of the contribution of vaccine-elicited cellular immunity to protecting memory CD4(+) T cells from virus-mediated destruction provide rational strategies for the development of this vaccine. This is therefore an ideal time to review our current understanding of HIV-1 and its control by the immune system, as well as the remaining problems that must be solved to facilitate the development of an effective vaccine against AIDS.

PMID:
17124514
DOI:
10.1038/nri1959
[Indexed for MEDLINE]

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