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Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18615-20. Epub 2006 Nov 21.

A two-step mechanism underlies the planar polarization of regenerating sensory hair cells.

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1
Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA. hernan.lopez@crg.es

Abstract

The restoration of planar cell polarity is an essential but poorly understood step toward physiological recovery during sensory-organ regeneration. Investigating this issue in the lateral line of the zebrafish, we found that hair cells regenerate in pairs along a single axis established by the restricted localization and oriented division of their progenitors. By analyzing mutants lacking the planar-polarity determinant Vangl2, we ascertained that the uniaxial production of hair cells and the subsequent orientation of their hair bundles are controlled by distinct pathways, whose combination underlies the establishment of hair-cell orientation during development and regeneration. This mechanism may represent a general principle governing the long-term maintenance of planar cell polarity in remodeling epithelia.

PMID:
17124170
PMCID:
PMC1656970
DOI:
10.1073/pnas.0608536103
[Indexed for MEDLINE]
Free PMC Article
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