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Arch Immunol Ther Exp (Warsz). 2006 Nov-Dec;54(6):381-91. Epub 2006 Nov 21.

Control of immune responses by immunoregulatory T cells.

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Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, 3010, Australia.


Immunoregulatory T cells play a key role in modifying the immune responses to self antigens, tumor antigens, and pathogenic organisms. This review summarizes recent data on naturally occurring CD4(+) regulatory T cells that constitutively express CD25 (CD25(+)T(reg)). We examine the markers that can be used to differentiate these cells from effector T cells, what is known about their mode of action in controlling the activity of effector T cells, the antigenic specificity of CD25(+)T(reg), and their ability to survive and to be selected in vivo. We also summarize specific information on the role of CD25(+)T(reg) in controlling anti-tumor responses, an area were manipulation of this subset holds particular clinical promise.

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