Format

Send to

Choose Destination
See comment in PubMed Commons below
Neth J Med. 2006 Nov;64(10):367-70.

The frequency of a positive family history for colorectal cancer: a population-based study in the Netherlands.

Author information

1
The Netherlands Foundation for the Detection of Hereditary Tumours and the Department of Gastroenterology, Leiden University Medical Centre, Leiden, the Netherlands.

Abstract

BACKGROUND:

Subjects with a positive family history of colorectal cancer (CRC) have an increased risk of developing CRC themselves. This risk depends on the number of affected relatives and the age at diagnosis.

AIM:

The aim of this study was to assess the prevalence of a positive family history of CRC, within a random cohort among the dutch population.

METHODS:

A total of 5072 subjects aged between 45 and 70 years were invited to fill in an anonymous questionnaire about the occurrence of CRC in their first-degree relatives (FDR).

RESULTS:

The questionnaire was returned by 3973 subjects (78.3%). Thirty responders (0.8%) had CRC themselves. Of all unaffected responders, 441 (11.2%) subjects reported a positive family history of CRC. Ninety (2.3%) responders reported having an FDR with CRC diagnosed before the age of 50, or reported two or more FDRs with CRC.

CONCLUSION:

The prevalence of a positive family history of CRC is substantial. Identification of this high-risk group by obtaining a thorough family history is the first step in targeting preventive measures.

PMID:
17122453
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for van Zuiden Communications
    Loading ...
    Support Center