Format

Send to

Choose Destination
Physiology (Bethesda). 2006 Dec;21:419-29.

The Amt/MEP/Rh family: structure of AmtB and the mechanism of ammonia gas conduction.

Author information

1
Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, California, USA.

Abstract

The atomic structures of the first members of the Amt/MEP/Rh family show that they are 11-crossing membrane proteins that form trimers in the membrane. Each monomer supports a hydrophobic channel that conducts NH(3) but not any water or ions. The reprotonation of NH(3) on the receiving side raises the pH on that side in the absence of metabolism of NH(3), and there is no transfer of protons through the protein.

PMID:
17119155
DOI:
10.1152/physiol.00051.2005
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center