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J Recept Signal Transduct Res. 2006;26(5-6):731-40.

GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia.

Author information

1
Institute of Pharmacology, University of Zurich, Zurich, Switzerland. mohler@pharma.unizh.ch

Abstract

Brain function is based on an exquisite balance between excitatory and inhibitory neurotransmission. GABAergic neurons provide the major inhibitory control. By controlling spike timing and sculpting neuronal rhythms they play a key role in regulating behavior. GABAergic neurons are highly diverse and operate with a corresponding diversity of GABAA receptor subtypes. In this article, the contribution of GABAA receptor deficits to central nervous system disorders, in particular anxiety disorders, epilepsy, schizophrenia and insomnia, is reviewed.

PMID:
17118808
DOI:
10.1080/10799890600920035
[Indexed for MEDLINE]

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