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Acta Neuropathol. 1991;81(3):345-8.

Hereditary diabetes insipidus: an immunohistochemical study of the hypothalamus and pituitary gland.

Author information

1
Department of Pathology (Neuropathology), Toronto General Hospital, Ontario, Canada.

Abstract

We report the histological findings in a case of hereditary diabetes insipidus (HDI) using vasopressin (VP) immunohistochemistry. The hypothalamus displayed a marked loss of magnocellular VP neurons, with preservation of the smaller cells. The neurohypophysis was severely atrophic with scanty immunoreactivity. Our results support the hypothesis that HDI results from a selective degeneration of VP neurons affecting chiefly the magnocellular elements projecting to the neurohypophysis. The sparing of the parvocellular component may reflect the projection of these neurons to non-pituitary targets.

PMID:
1711761
DOI:
10.1007/bf00305879
[Indexed for MEDLINE]

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