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Nat Rev Neurosci. 2006 Dec;7(12):932-41.

Axonal conduction and injury in multiple sclerosis: the role of sodium channels.

Author information

1
Department of Neurology and Center for Neuroscience and Regeneration Research, Yale School of Medicine, New Haven, Connecticut 06510, USA. stephen.waxman@yale.edu

Abstract

Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Recent studies have implicated specific sodium channel isoforms as having an important role in several aspects of the pathophysiology of MS, including the restoration of impulse conduction after demyelination, axonal degeneration and the mistuning of Purkinje neurons that leads to cerebellar dysfunction. By manipulating the activity of these channels or their expression, it might be possible to develop new therapeutic approaches that will prevent or limit disability in MS.

PMID:
17115075
DOI:
10.1038/nrn2023
[Indexed for MEDLINE]

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