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Nat Neurosci. 2006 Dec;9(12):1474-6. Epub 2006 Nov 19.

Cochlear efferent feedback balances interaural sensitivity.

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1
Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, Massachusetts 02114, USA.

Abstract

Neurons in the lateral superior olive (LSO) compute sound location based on differences in interaural intensity, coded in ascending signals from the two cochleas. Unilateral destruction of the neuronal feedback from the LSO to the cochlea, the lateral olivocochlear efferents, disrupted the normal interaural correlation in response amplitudes to sounds of equal intensity. Thus, lateral olivocochlear feedback maintains the binaural balance in neural excitability required for accurate localization of sounds in space.

PMID:
17115038
PMCID:
PMC1806686
DOI:
10.1038/nn1807
[Indexed for MEDLINE]
Free PMC Article
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