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J Am Podiatr Med Assoc. 2006 Nov-Dec;96(6):482-8.

Efficacy of concentrated autologous platelet-derived growth factors in chronic lower-extremity wounds.

Author information

1
Division of Podiatric Surgery, Department of Orthopaedics, Mount Sinai Hospital of Queens, Mount Sinai School of Medicine, Astoria, NY, USA.

Abstract

The efficacy of concentrated autologous platelet-derived growth factors in the healing and closure of chronic lower-extremity wounds was evaluated in 24 patients with 33 lower-extremity wounds treated previously for at least 6 months using traditional methods. Surgical wound debridement was performed to convert chronic ulcers into acute wounds. Concentrated autologous platelet-derived growth factors and thrombin were applied to the wound bases and protected with a nonadhering compression dressing that remained intact for 7 days. Wounds were evaluated and the concentrate was reapplied every 2 weeks. Wound closure and complete epithelialization was achieved in 20 wounds. Seventy-five percent or greater wound closure was obtained in three wounds, 50% to 74% closure in three wounds, and 25% to 49% closure in two wounds. Five wounds displayed no improvement. Mean time to complete closure was 11.15 weeks. The application of concentrated autologous platelet-derived growth factors and thrombin resulted in substantial wound healing and wound-diameter reduction. This technique constitutes a safe and effective treatment option and avoids lengthy treatment periods that increase the potential for infection.

PMID:
17114601
[Indexed for MEDLINE]

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