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Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18320-5. Epub 2006 Nov 17.

Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth.

Author information

1
Department of Neurosurgery, Children's Hospital, Boston, MA 02115, USA. nina.irwin@childrens.harvard.edu

Abstract

The growth of axons is fundamental to the development and repair of brain circuitry. We show here that Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression (via siRNAs) or its function (by a dominant-negative mutant) blocks axon outgrowth. Inosine, a purine nucleoside that stimulates axon outgrowth, activates Mst3b kinase activity, whereas 6-thioguanine, a purine analog that blocks outgrowth, inhibits the activity of this kinase. These findings place Mst3b as a key regulator of axon outgrowth and help explain the purine sensitivity of this process.

PMID:
17114295
PMCID:
PMC1838749
DOI:
10.1073/pnas.0605135103
[Indexed for MEDLINE]
Free PMC Article
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