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Curr Opin Immunol. 1991 Feb;3(1):65-70.

Role of nitric oxide synthesis in macrophage antimicrobial activity.

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1
Department of Medicine, Cornell University Medical College, New York, New York 10021.

Abstract

Research over the past 5 years has demonstrated that immunologic activation of mouse macrophages induces the activity of nitric oxide synthase, which oxidizes a guanidino nitrogen of L-arginine, yielding citrulline and the reactive radical, nitric oxide. A review of the biochemistry and immunologic regulation of this pathway in macrophages provides a backdrop against which to evaluate its effector functions. Reports published in the past 2 years suggest that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.

PMID:
1711326
[Indexed for MEDLINE]
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