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Nat Immunol. 2006 Dec;7(12):1266-73.

The TREM receptor family and signal integration.

Author information

1
Washington University School of Medicine, Department of Pathology and Immunology, Saint Louis, Missouri 63110, USA.

Abstract

TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.

PMID:
17110943
DOI:
10.1038/ni1411
[Indexed for MEDLINE]

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