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Nat Immunol. 2006 Dec;7(12):1258-65.

Myeloid C-type lectins in innate immunity.

Author information

1
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.

Abstract

C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.

PMID:
17110942
DOI:
10.1038/ni1417
[Indexed for MEDLINE]

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