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Nat Immunol. 2006 Dec;7(12):1237-42.

The innate signaling of dangers and the dangers of innate signaling.

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1
Unité de Pathogénie Microbienne Moléculaire, Unité INSERM 786, and the Howard Hughes Medical Institute International Program, Institut Pasteur, 75724 Paris, France. psanson@pasteur.fr

Abstract

The innate immune system of mammals has been forged by coevolution with microbes in response to the double constraint of preserving a symbiotic interaction with commensal flora and eliminating intrusion of those commensals or invasion by pathogens. Thus, a 'sensing' network, accompanied by or lacking inflammatory responses, is controlled by elaborate mechanisms of regulation that maintain balance in the basal state. A growing number of non-Toll-like innate immune receptors is recognized as part of this surveillance network.

PMID:
17110939
DOI:
10.1038/ni1420
[Indexed for MEDLINE]
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