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Clin Lab Med. 2006 Dec;26(4):847-70.

Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy.

Author information

1
LipoScience Inc., 2500 Sumner Boulevard, Raleigh, NC 27616, USA.

Abstract

Laboratory measurements of plasma lipids (principally cholesterol and triglycerides) and lipoprotein lipids (principally low-density lipoprotein [LDL] and low-density lipoprotein [HDL] cholesterol) are the cornerstone of the clinical assessment and management of atherosclerotic cardiovascular disease (CVD) risk. LDL particles, and to a lesser extent very-low-density lipoprotein [VLDL] particles, cause atherosclerosis, whereas HDL particles prevent or reverse this process through reverse cholesterol transport. The overall risk for CVD depends on the balance between the "bad" LDL (and VLDL) and "good" HDL particles. Direct assessment of lipoprotein particle numbers us now possible through nuclear magnetic resonance spectroscopic analysis.

PMID:
17110242
DOI:
10.1016/j.cll.2006.07.006
[Indexed for MEDLINE]

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