Format

Send to

Choose Destination
Nat Rev Cancer. 2006 Dec;6(12):924-35. Epub 2006 Nov 16.

Cancer as an evolutionary and ecological process.

Author information

1
Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

Abstract

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.

PMID:
17109012
DOI:
10.1038/nrc2013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center