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Rev Infect Dis. 1991 Mar-Apr;13 Suppl 4:S279-84.

The lipopolysaccharide of Shigella bacteria as a virulence factor.

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1
Karolinska Institute, Department of Clinical Bacteriology, Huddinge Hospital, Sweden.

Abstract

The virulence factors of the lipopolysaccharide of Shigella species bacteria include the endotoxic activities of the lipid A component of the molecule and the ability of the polysaccharide chain--the core and the O-antigenic polysaccharide--to provide the bacterium with resistance to host defense mechanisms such as opsonization, phagocytosis, and intracellular killing. Structural features of the lipopolysaccharides of four Shigella species-S. dysenteriae, S. flexneri, S. boydii, and S. sonnei--are described.

[Indexed for MEDLINE]

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