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Cell Cycle. 2006 Nov;5(22):2557-60. Epub 2006 Nov 15.

A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription.

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Howard Hughes Medical Institute, Department of Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093-0648, USA.


While diverse enzymatic activities are required for transcriptional initiation, a central question remains whether additional enzymatic activities involved in other cellular processes may also be critical for regulated gene activation. Recently, we reported that signal-dependent activation of gene transcription requires topoisomerase IIbeta (Topo IIbeta)-dependent, nucleosome-specific, transient double-stranded DNA break formation with subsequent activation of poly(ADP-ribose) polymerase-1 (PARP-1) enzymatic function, which causes local changes of chromatin architecture (Ju et al., Science 2006; 312:1798-802). Here, we discussed that possible molecular mechanism underling Topo IIbeta/PARP-1/DNA-PK network in transcriptional initiation and many intriguing issues remain to be solved in the future.

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