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J Appl Microbiol. 2006 Dec;101(6):1301-8.

Transmission of Salmonella enterica serotype Typhimurium in poultry with and without antimicrobial selective pressure.

Author information

1
US Department of Agriculture, Agricultural Research Service, Bacterial Epidemiology and Antimicrobial Resistance Research Unit, Athens, GA 30605, USA.

Abstract

AIMS:

To determine the effect of antimicrobial selective pressure on the transmission of antimicrobial resistant and sensitive strains of Salmonella in poultry.

METHODS AND RESULTS:

Eight pens housed 12 broiler chicks each. Two chicks in four of the pens were inoculated with a Salm. Typhimurium strain resistant to 12 antimicrobials (including tetracycline), and two chicks in each of the four other pens were inoculated with a strain sensitive to all antimicrobials tested. Two pens inoculated with each strain were treated with chlortetracycline and two were not. Chicks were killed on day 7 and caeca were cultured for Salmonella. Experiments were performed independently twice. Chicks exposed to pen mates inoculated with the resistant strain and treated with tetracycline were 90% positive for Salmonella; whereas 60% of chicks given no antimicrobials were positive. Chicks exposed to the sensitive strain were 95% positive with tetracycline treatment and 90% positive without treatment.

CONCLUSIONS:

A multidrug-resistant Salm. Typhimurium strain had significantly increased transmission when chicks were treated with tetracycline. Transmission of a sensitive strain was not inhibited by antimicrobial selective pressure at recommended therapeutic dose.

SIGNIFICANCE AND IMPACT OF THE STUDY:

This study demonstrates that antimicrobial usage may influence the transmission of antimicrobial-resistant pathogens in poultry.

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