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J Am Chem Soc. 2006 Nov 22;128(46):14796-7.

Oxidative amide synthesis and N-terminal alpha-amino group ligation of peptides in aqueous medium.

Author information

1
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.

Abstract

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.

PMID:
17105276
DOI:
10.1021/ja064479s
[Indexed for MEDLINE]

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