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J Am Chem Soc. 2006 Nov 22;128(46):14768-9.

A cellular FRET-based sensor for beta-O-GlcNAc, a dynamic carbohydrate modification involved in signaling.

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Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station, A5300 Austin, TX 78712-0265, USA.


beta-O-N-Acetyl-d-glucosamine (O-GlcNAc) is a dynamic carbohydrate modification that is involved in cell signaling and has been implicated in a variety of disease states, including Alzheimer's and type-II diabetes. Despite the importance of this modification, little is known about the spatial and temporal localization of O-GlcNAc during signaling. This is due to the lack of methods for the study of O-GlcNAc in living cell systems. Herein we report the first genetically encoded FRET-based sensor for the detection of O-GlcNAc dynamics in live mammalian cells.

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