Send to

Choose Destination
Angew Chem Int Ed Engl. 2006 Nov 20;45(45):7506-25.

Modern aldol methods for the total synthesis of polyketides.

Author information

Chemisches Institut, Humboldt-Universit├Ąt zu Berlin, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.


The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal-complex-catalyzed, organocatalytic, and biocatalytic methods.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center